Title: Brain dynamics of Parkinson's disease

Speaker: Herberto Dhanis (Swiss National Science Foundation Research Fellow at the Functional Imaging Laboratory (UCL))

Location: In Person & Online via Zoom

Abstract: Beyond a movement disorder, Parkinson’s disease is a multifaceted condition with a myriad of non-motor symptoms, and while protein-pathology damage to the brainstem is responsible for the motor presentation, the mechanisms underlying non-motor symptoms surpass atrophy alone.

In this talk, I will present how global changes in functional connectivity underpin non-motor symptoms across early and late stages of the disease. I will discuss how the breakdown of brainstem-cortical connectivity contributes to early stages of the disease (autonomic failure) and how losing the ability to engage and promote different global brain states of connectivity underpins the cognitive and psychiatric (hallucinations) phenotype of Parkinson’s disease.

Bluesky: @herbertodhanis
LinkedIn: https://www.linkedin.com/in/herberto-dhanis/